Fig. 10. Heads stained for bone (dark purple) and cartilage (blue) at E18.5. Superior semicircular canal (SSC), tympanic ring (TR) and the basioccipital bone (BO) are marked. In Foxi1^+/+ and Foxi1^+/- an arrowhead indicates the ossification centers of the middle ear bones. Normal morphology is seen in Foxi1^+/+ and Foxi1^+/- mice; Foxi1^-/- animals display a clearly aberrant integration of the otic capsule in the temporal bone as evident by excessive ectopic cartilage condensation/bone formation in both the cochlea (arrowheads) and the vestibulum (arrows). Scale bar: 200 µm.

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