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Development 130, e902-e902 (2003)
Copyright © 2003 The Company of Biologists Limited

In this issue

Nodal signalling in LR asymmetry


Recent progress in understanding vertebrate left/right (LR) patterning has raised important questions concerning the role of Nodal in this process. Nodal expression on the left side of the lateral plate during development acts as a left-side determinant that induces left-side-specific morphogenesis. To investigate how Nodal expression is initiated here, Yamamoto and colleagues generated conditional mouse mutants in which Foxh1 expression — Foxh1 mediates Nodal signalling — was inactivated in the lateral plate mesoderm (LPM). Their results on p. 1795 show that Nodal signalling induces the initiation and expansion of asymmetric Nodal expression in LPM, as well the expression of Lefty1 at the midline. These findings also shed light on how asymmetric signals are transferred between embryonic tissues during LR patterning: Nodal activity probably travels from the node to the left LPM and from here to the midline.


Related articles in Development:

Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate
Masamichi Yamamoto, Naoki Mine, Kyoko Mochida, Yasuo Sakai, Yukio Saijoh, Chikara Meno, and Hiroshi Hamada
Development 2003 130: 1795-1804. [Abstract] [Full Text]  




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