Development 130, e904-e904 (2003)
Copyright © 2003 The Company of Biologists Limited
Surprising Bazooka functions
Improving our understanding of the mechanisms that govern cell motility and
invasion is crucial for understanding development and how these processes go
awry in metastasis. Border cell migration during Drosophila oogenesis
is a well-studied model of invasive and directed migration, which has now been
analysed by Abdelilah-Seyfried et al. in flies mutant for bazooka and
DaPKC (components of an epithelial polarity- and adhesion-regulating
complex) and for the tumour suppressor genes, dlg1 and lgl.
Their findings on p. 1927 show
that the aberrant invasion of germ cells by dlg1- follicle
epithelial cells surprisingly requires wild-type Bazooka function, possibly
because Bazooka stabilizes adhesion between the invading somatic cells and
their germ-cell substratum. By contrast, Bazooka function is dispensable for
border cell invasion and motility, perhaps because it mediates cell adhesion
within the migrating border cell cluster. These findings reveal distinct
functions for Bazooka during different types of epithelial cell invasion.
Related articles in Development:
- Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia
- Salim Abdelilah-Seyfried, Daniel N. Cox, and Yuh Nung Jan
Development 2003 130: 1927-1935.
[Abstract]
[Full Text]
