QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online December 17, 2003

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

How C. elegans maintains its germline

In stem cell populations, proliferation and differentiation are finely balanced to ensure that the stem cells are maintained but do not overgrow and that non-renewable tissues are generated as required. On p. 93, Hansen et al. report that in the C. elegans germline, the accumulation pattern of GLD-1, an RNA-binding protein, controls the spatially determined balance between proliferation and meiosis. They show that at the distal end of the gonad, a low GLD-1 concentration allows stem cell proliferation; whereas, at more proximal regions, a high GLD-1 concentration promotes the entry of stem cells into meiosis and, ultimately, differentiation into gametes. To explain the accumulation pattern of GLD-1, the researchers propose that GLP-1/Notch signalling and FBF (a homologue of the Drosophila RNA-binding protein Pumilio) inhibit GLD-1 accumulation distally, while NOS-3 (a homologue of the Drosophila translational regulator Nanos) and the poly(A)polymerase GLD-2 act redundantly to promote GLD-1 accumulation proximally.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation

Dave Hansen, Laura Wilson-Berry, Thanh Dang, and Tim Schedl
Development 2004 131: 93-104. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?