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First published online December 17, 2003

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New BMP inhibitor hits the joint

Bone morphogenetic proteins (BMPs) are important in many developmental processes but were originally identified as factors inducing the ectopic formation of bone and cartilage. On p. 229, Nakayama and colleagues bring the BMP story full circle by identifying a new chordin-like secreted BMP inhibitor, CHL2, that is expressed almost exclusively in the chondrocytes of developing joint cartilage. The researchers show that recombinant mouse CHL2 (mCHL2) interacts directly with several BMPs and inhibits many BMP-dependent processes in vitro. In particular, the addition of exogenous mCHL2 to a chondrogenic culture system reduces cartilage matrix deposition and mineralisation. The findings indicate that CHL2 may regulate the formation and maintenance of articular cartilage. Finally, CHL2 expression is upregulated in middle zone chondrocytes of osteoarthritic joint cartilage; thus, this novel BMP inhibitor could also be involved in the pathogenesis of degenerative joint disease.

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Related articles in Development:

A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage

Naoki Nakayama, Chun-ya E. Han, Linh Cam, Jae I. Lee, Jim Pretorius, Seth Fisher, Robert Rosenfeld, Sheila Scully, Ryuichi Nishinakamura, Diane Duryea, Gwyneth Van, Brad Bolon, Takashi Yokota, and Ke Zhang
Development 2004 131: 229-240. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?