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First published online December 17, 2003

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Mapping the sense of smell

In the Drosophila olfactory system, axons of the olfactory receptor neurons (ORNs), each of which typically expresses a single specific olfactory receptor, converge onto specific glomeruli in the antennal lobe to create a spatial odour map. Olfactory information is relayed from glomeruli to higher brain centres by projection neurons (PNs), each of which forms synaptic connections with a single class of ORNs. To investigate how this wiring is established, Jefferis et al. have used `mosaic analysis with a repressible cell marker', MARCM, to study PN development at single-cell resolution (see p. 117). Surprisingly, given that previous work suggested that ORNs are central to olfactory map formation, PN dendrites established a prototypic neural map in the antennal lobe before ORN arrival. The researchers propose that this coarse PN dendritic map interacts with a coarse map formed by developing ORNs to generate the mature glomerular organisation.

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Related articles in Development:

Developmental origin of wiring specificity in the olfactory system of Drosophila

Gregory S. X. E. Jefferis, Raj M. Vyas, Daniela Berdnik, Ariane Ramaekers, Reinhard F. Stocker, Nobuaki K. Tanaka, Kei Ito, and Liqun Luo
Development 2004 131: 117-130. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?