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First published online December 17, 2003

Development 131, 104e (2004)
© The Company of Biologists Limited
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In this issue

Mapping the sense of smell


In the Drosophila olfactory system, axons of the olfactory receptor neurons (ORNs), each of which typically expresses a single specific olfactory receptor, converge onto specific glomeruli in the antennal lobe to create a spatial odour map. Olfactory information is relayed from glomeruli to higher brain centres by projection neurons (PNs), each of which forms synaptic connections with a single class of ORNs. To investigate how this wiring is established, Jefferis et al. have used `mosaic analysis with a repressible cell marker', MARCM, to study PN development at single-cell resolution (see p. 117). Surprisingly, given that previous work suggested that ORNs are central to olfactory map formation, PN dendrites established a prototypic neural map in the antennal lobe before ORN arrival. The researchers propose that this coarse PN dendritic map interacts with a coarse map formed by developing ORNs to generate the mature glomerular organisation.


Related articles in Development:

Developmental origin of wiring specificity in the olfactory system of Drosophila
Gregory S. X. E. Jefferis, Raj M. Vyas, Daniela Berdnik, Ariane Ramaekers, Reinhard F. Stocker, Nobuaki K. Tanaka, Kei Ito, and Liqun Luo
Development 2004 131: 117-130. [Abstract] [Full Text]  




This Article
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