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Fig. 4. mCHL2 mRNA expression in cartilage. In situ hybridization (ISH) for CHL2 in
normal mouse embryos, depicted in paired bright-field (left) and dark-field
(right) panels. (A) Expression of CHL2 mRNA at the costochondral junction, at
E17.5. Note CHL2 in chondrocytes on both sides of the junction. (B)
Transverse section through sternum, at E18.5. Signal is present in areas where
ribs converge. (C,D) ISH for CHL2 in the adult knee. Weak
CHL2 expression is present over the articular cartilage surface of
the femoral head and patella, but not in growth plate chondrocytes. Boxed
areas in C shown at a higher magnification in D in which the signal can be
seen in chondrocytes on both sides of the joint. (E,F) Expression of
CHL2 in adult vertebral articulation. Signal occurs in superficial
articular chondrocytes on both sides of the zygapophyseal or facet joint. The
boxed area in E is shown at a higher magnification in F, revealing signal
localization over the superficial zone chondrocytes. dv, dorsal (superior)
vertebra; vv, ventral (inferior) vertebra. Arrowheads indicate CHL2-positive
chondrocytes.
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