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Fig. 6. Expression of CHL2 mRNA in diseased cartilage. (A) In situ hybridization
for CHL2 in human adult knee joints, depicted in paired bright-field (left)
and dark-field (middle) panels, and accompanied by a higher magnification view
(bright field panel, right). Expression of CHL2 mRNA in normal knee cartilage
(femur, 55-year old female). Note that CHL2 is localized on articular
chondrocytes (right). However, CHL2+ chondrocytes are scattered
throughout the cartilage. Weak signals are also visible in superficial zone
chondrocytes. (B,C) Expression of CHL2 in osteoarthritic (OA) knee
cartilage (B: 73-year-old male with OA, degenerative joint disease (DJD), and
chronic proliferative synovitis; C: 48-year-old female with DJD). Signal is
strongly induced in middle zone chondrocytes, but absent in superficial zone
chondrocytes. (D) Expression of CHL2 in rheumatoid arthritic knee
cartilage (80-year-old female with RA). Weakly positive chondrocytes are
scattered throughout the cartilage. (E,F) Expression of CHL2 mRNA in hind paws
of rats with collagen-induced arthritis, depicted in paired bright-field
(left) and dark-field (middle) panels. CHL2 signal is weakly expressed in
normal chondrocytes (E), and is not substantially elevated in animals with
severe immune-mediated disease (F). Arrowheads indicate CHL2-positive
chondrocytes. sz, superficial zone; mz, middle zone; dz, deep zone.
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