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Fig. 5. Developmental changes in lacZ expression with the F3placZ
construct. Lateral and frontal views of the F3placZ transgenic
embryos at 8.5 (A,B), 9.5 (C), 10.5 (D), 12.5 (I,J) and 13.5 (M) dpc, and a
dorsal view at 13.5 dpc (N), following ß-galactosidase staining.
Transverse sections of transgenic embryos at 10.5 (E-H) and 12.5 (K,L) dpc.
Sagittal sections of embryos at 10.5 (H) and 12.5 (L) dpc. Whole-mount in situ
hybridization analysis of noggin mRNA indicates that mouse noggin expression
is evident in the roof of the neural tube, including at the level of the
diencephalon (O, arrowheads). Lateral view of the F3hsplacZ
transgenic embryo at 10.5 dpc, following ß-galactosidase staining (P).
cp, choroid plexus; d, diencephalon; he, cortical hem; lt, lamina terminalis;
lv, lateral ventricle; m, mesencephalon; t, telencephalon.
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