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Fig. 6. Morphogen distribution in the EXT (ttv⁵²⁴botv⁵¹⁰) mutant clones. Hh, Dpp and Wg proteins are significantly reduced in the mutant clones, both in the morphogen-expressing region (A-C) and in the receiving region (D-F). (A) In ttv⁵²⁴botv⁵¹⁰ mutant clones (marked by the absence of GFP), Hh protein is severely reduced, whereas hh-lacZ expression was not downregulated. (B) Both Dpp protein and dpp expression levels are decreased in the ttv⁵²⁴botv⁵¹⁰ clones. (C) Both Wg protein and wg expression levels are decreased in the ttv⁵²⁴botv⁵¹⁰ clones. In the morphogen-receiving region, each of Hh, Dpp-GFP and Wg protein was significantly decreased in the mutant clones (arrowheads; D-F).

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