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Fig. 7. Models of factors regulating GLD-1 accumulation levels. (A) Schematic
representation of GLD-1 accumulation in the distal germline with factors
inhibiting accumulation (barred lines) and factors promoting accumulation
(arrows). GLP-1/Notch signaling and FBF sequentially inhibit GLD-1
accumulation at the distal-most end of the germline, while GLD-2 and NOS-3
redundantly promote GLD-1 accumulation. (B,C) Alternative models describing
the genetic relationships between glp-1 signaling and nos-3
and gld-2 relative to GLD-1 accumulation. (B) glp-1
signaling inhibits GLD-1 accumulation by inhibiting the redundant activities
of nos-3 and gld-2. Alternatively (C), glp-1
signaling works in parallel with nos-3 and gld-2, and GLD-1
accumulation reflects the net influence of these factors. (D) Genetic pathway
regulating GLD-1 accumulation. In the distal end fbf and gene
x inhibit nos-3 and gld-2, respectively. More
proximally, where glp-1 signaling is low, nos-3 and
gld-2 promote GLD-1 accumulation. (E) Genetic model of genes
functioning in the proliferation versus meiotic entry decision. glp-1
signaling inhibits the gld-1 and gld-2 pathways in the most
distal end. For gld-1, this inhibition involves fbf-1/-2
inhibiting the promotion of gld-1 by nos-3. gld-2 is
inhibited by something (x) other than, or in addition to,
fbf-1/-2. As glp-1 signaling is reduced in more proximal
cells, nos-3 and gld-2 promote GLD-1 protein accumulation,
and both gld-1 and gld-2 promote meiotic development and/or
inhibit proliferation (see text).
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