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First published online May 5, 2004

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Twists and turns in mesodermal patterning

Early in development, uncommitted mesodermal cells are patterned into repetitive segments and allocated to specific tissue fates - for example, somatic or gut muscles - depending on their position within the segments. In Drosophila, mesodermal subdivision is controlled by levels of the bHLH transcription factor Twist, and, on p. 2359, Tapanes-Castillo and Baylies report that Notch signalling regulates twist expression through a complex network of transcriptional regulators. They show that Notch signalling, mediated by Suppressor of Hairless, not only directly represses twist expression during subdivision of mesodermal segments, but also indirectly regulates twist by activating repressors of twist. The researchers propose that proteins encoded by the Enhancer of split complex and the HLH gene extra machrochaetae are the repressors of twist, and suggest that a similar Notch signalling mechanism may act in mesodermal differentiation in vertebrates.

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Related articles in Development:

Notch signaling patterns Drosophila mesodermal segments by regulating the bHLH transcription factor twist

Alexis Tapanes-Castillo and Mary K. Baylies
Development 2004 131: 2359-2372. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?