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Fig. 2. Examples of negative regulators of proliferation. (A) In the
Drosophila eye, Shar-pei (Salvador) controls cell number by
inhibiting cell proliferation and promoting cell death. This is indicated by
the increase of interommatidial cells in the sharpei/salvador mutant
compared with wild type. (B) In the mouse cochlea, hair cells (brackets)
re-enter the cell cycle in the absence of p19Ink4d. Myosin VIIa is
a marker of postmitotic, differentiated hair cells, and BrdU incorporation is
shown in a p19Ink4d-/- hair cell (arrow). In this experiment, BrdU
was given to animals after the period when hair cells are generated. (C) In
the mouse retina, differentiated amacrine cells [Glycine Transporter 1 (GlyT1)
immunoreactive] and horizontal cells (Calbindin immunoreactive) reenter the
cell cycle as a result of the combined absence of p19Ink4d and
p27Kip1, as indicated by BrdU incorporation (arrows). Similar to
the experiment shown in B, BrdU was given to animals after the period when
amacrine and horizontal cells are generated. Panels modified with permission
from Kango-Singh et al., Chen et al. and Cunningham et al.
(Kango-Singh et al., 2002;
Chen et al., 2003;
Cunningham et al., 2002).
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