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Fig. 5. Ftz converts Runt from an activator to a repressor of slp1. (A)
Embryos mutant for ftz express slp1 in the anterior half of
the even-numbered parasegments, resulting in six-cell wide stripes. (B) The
ftz mutant phenotype and the way in which this expanded expression is
accounted for by Runt+Opa dependent activation. Note that run
expression is not significantly altered in ftz mutant embryos at this
stage (Klingler and Gergen,
1993). (C) Ectopic Runt expression in ftz mutant embryos
activates slp1 throughout the presegmental region. This embryo was
obtained from a cross between a female heterozygous for NGT40, NGTA
and the ftz[11] mutation with a male homozygous for
UAS-runt[232] and heterozygous for ftz[11]. The level of
NGT-driven Runt obtained with this combination does not fully
overcome Eve-dependent repression, resulting in a few thin stripes of cells
with reduced slp1 expression. Runt+Opa-dependent activation (D)
results in the slp1 pattern shown in C. The effects of
NGT-driven Ftz on slp1 is shown in E and interpreted in F.
The embryo in E is from a mating between homozygous NGT40 females and
homozygous UAS-ftz[261] males. The effects of co-expressing Runt and
Ftz are shown in G and interpreted in H. The embryo in G is from a mating
between homozygous NGT40 females and males homozygous for both
UAS-runt[232] and UAS-ftz[261].
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