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Fig. 8. A cellular model for the control of glial migration by retinal innervation.
A small number of glia (red) migrate into the target region for photoreceptor
axons prior to ommatidial development, and are ready to provide initial
guidance cues to the first photoreceptor axons (green; top two panels). These
early photoreceptor axons trigger the elaboration of the axonal scaffold for
glial migration (blue; third panel from top), which extends in stereotypical
fashion to establish the multiple pathways (not depicted). Glia generated in
the Wg subdomain 1 (yellow) can then migrate to target destinations, such as
the lamina (shown, bottom panel). Subsequent migration may be independent of
continued retinal axon ingrowth (see the text). Through this mechanism, the
distribution of glia throughout the optic lobe is coordinated with innervation
by the photoreceptor axons.
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