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Fig. 4. Rescue of skeletal homeosis and hoxa2b expression in moz mutants by the histone deacetylase inhibitor Trichostatin A (TSA). (A-D) Ventrolateral views of 4-day-old wild type (A,C) and moz mutant (B,D) larvae treated with DMSO (A,B) or TSA (C,D) stained with Alcian Green. TSA rescues many aspects of the skeletal phenotype, including deletion of the HM cartilage (arrowhead) and fusion and inversion of the ventral second arch cartilage (arrow; see Table 3). (E-H) Lateral views of hoxa2b expression at 33 hpf in wild type (E,G) and moz mutants (F,H) treated with DMSO (E,F) or TSA (G,H). TSA treatment rescues hoxa2b expression in moz mutants. e, eye. Scale bars: 50 µm.





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