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Fig. 9. Stable ectopic expression of bapx1 in the moz mutant
second arch. Ventral (A-C,F-I) and lateral (D,E) views of bapx1
expression in whole-mount wild-type (A,D,F,H), moz mutant (B,E,G,I)
and hoxa2b + hoxb2a-MO co-injected animals (C) at 33 hpf
(A-E), 54 hpf (F,G) and 4 days (H,I). (A-E) bapx1 expression, which
is normally restricted to a patch of first arch mesenchyme (A,D), is
ectopically expressed (arrowhead in E) in the second arch of moz
mutants (B,E) and hoxa2b+hoxb2a-MO co-injected animals (C). (F-I)
Ectopic bapx1 expression (arrowheads) is maintained in second arch
mesenchyme of moz mutants. (J,K) Reduction of bapx1 function
in wild type (J) and moz mutant (K). Reducing bapx1 function
in wild type causes specific loss of the jaw joint (asterisk in J), while
reducing function of bapx1 in moz mutants causes loss of
both first and second arch joints (asterisks in K). Reduction of
bapx1 function in moz mutants also can rescue the ventral
arch one and two fusions. The first two pharyngeal arches are numbered. e,
eye. Scale bars: 50 µm.
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