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Fig. 8. Analysis of growth plates from control, Hif1a null and
Hif1a/Vhlh null mice. (A-C,H-J) Hematoxylin and Eosin staining of
histological sections of control (A,H), Hif1a null (B,I) and
Hif1a/Vhlh null mice (C,J), at E14.5 (A-C) and birth (H-J). (E-G)
Evidence for increased cell proliferation rates in Hif1a null and
Hif1a/Vhlhnull chondrocytes. Detection of BrdU-labeled chondrocytes
in histological sections of E14.5 control (E), Hif1a null (F) and
Hif1a/Vhlh null (G) proximal tibia growth plates. (D) Percentage of
BrdU-labeled cells; bars represent mean percentages (±s.d.) of
BrdU-labeled chondrocytes in Hif1a null, Hif1a/Vhlh null and
wild-type (WT) growth plates at E14.5, separated into proliferating zone (PZ)
and resting zone (RZ). Statistical differences in each zone were identified
using the unpaired t-test. **P<0.01.
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