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First published online May 17, 2004

Development 131, 1106e (2004)
© The Company of Biologists Limited
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In this issue

Turning stem cells into progenitors

The isolation of human embryonic stem (ES) cells in 1998 advanced the dream of replacement tissues on demand but we still need to learn how to turn ES cells efficiently into different cell types. On p. 2749, Park and colleagues describe a temporal sequence of factors that turns murine ES cells into FLK1- and SCL-expressing haematopoietic and endothelial progenitors. The researchers show that BMP4 is required for the sequential generation of FLK+ and SCL+ cells from ES cells in serum-free conditions. Expansion of the SCL+ cells is mediated by VEGF, and, they report, TGFß1 and activin A inhibit and augment, respectively, the effects of VEGF. These and other results presented by Park et al. bring tissue engineering a step closer, at least for haematopoietic and endothelial cells.


Related articles in Development:

A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells
Changwon Park, Iva Afrikanova, Yun Shin Chung, Wen Jie Zhang, Elizabeth Arentson, Guo hua Fong, Alexander Rosendahl, and Kyunghee Choi
Development 2004 131: 2749-2762. [Abstract] [Full Text]  




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