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Fig. 4. schizo encodes two Arf-GEF-like proteins. (A) Schematic drawing of
the schizo locus. Two transcripts are represented by EST clones
identified by the BDGP (t1 RE44556, t2 LP01489).
Transcription is from left to right. The location of two P-element insertions
is indicated, both l(3)3 and P224 lead to a strong
schizo mutant phenotype (data not shown). (B) The two deduced Schizo
proteins are characterized by three sequence domains: an IQ domain, which
might confer Calmodulin binding, a Sec7 and a Plecstrin homology (PH) domain,
which are a signature of guanine exchange factors. (C) schizo is
expressed maternally and appears to be negatively regulated by segmentation
genes (D). (E,F) schizo is broadly expressed during early
development. (G) At the extended germ band stage expression of schizo
in the ectoderm is reduced. (H) schizo continues to be expressed in
the central nervous system (CNS). The arrow denotes expression in the CNS
midline.
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