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Fig. 4. The function of PBL in cell migration is independent of its function in cytokinesis. (A-C) Embryos at stage 10 stained for EVE (blue) and TWI and ßGal (brown). In the wild-type (A) and stg^7M homozygous embryos (B), eleven eve-positive hemisegments are stained on either side of the embryo. In pbl³, stg^7M double mutant embryos (C), the number of eve-positive hemisegments is strongly reduced, reminiscent of pbl single mutant embryos. (D-F) Cell shape changes in twi::CD2; pbl³/pbl³ (D), twi::CD2; stg^7M/stg^7M (E), and twi::CD2; pbl³,stg^7M/pbl³,stg^7M double mutant (F) embryos as visualized with anti CD2 (red) and anti TWI (green) staining. Protrusive activity in phase 2 is absent in pbl and pbl,stg double mutant embryos, while it can still be observed in stg single mutants. Note bi-nucleated cells are present in pbl mutants (arrows in D), but are absent in stg and pbl,stg double mutants (arrows in E,F).

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