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Fig. 6. FGF gene loss of function alters the expression of RAR signaling pathway components in microinjected embryos. Embryos were microinjected unilaterally into one blastomere at the two- or four-cell stage with 1 ng of XFD mRNA and ß-galactosidase mRNA as lineage tracer. Embryos were allowed to develop until controls reached stage 11 then fixed and processed for whole-mount in situ hybridization with the probes (A,B) XCAD3, (C,D) XRAR{alpha}, (E,F) RALDH2 or (G,H) CYP26.





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