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Fig. 6. Brk is a potential D-h repressor. (A) D-h-GFP expression
(green) relative to brk-lacZ expression (red) in a wild-type leg
disc. (B,C) brk-lacZ expression in a wild-type leg disc (B) and a dpp
hypomorph (dppd6/dppd12) leg disc (C). (D,G) Overexpression of
brk, in UAS-brk/+; dpp-Gal4/+ legs, results in
drastic reduction of D-h-GFP expression (D) and
D-h-C-GFP (G), while HHRE-GFP (E) and
D-h-CB-GFP are still expressed (F). It appears that in legs
overexpressing brk, there are fewer HHRE-GFP and
D-h-CB-GFP-expressing cells. This is probably due to compromised
growth of leg discs when Brk levels are elevated near the AP boundary
(Jazwinska et al., 1999).
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