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Fig. 9. Model for D-h regulation. Ci acts through the HHRE to activate
expression in a broad AP boundary stripe that can be divided into zones 1
(blue) and 2 (red). The intact D-h element directs expression only in
zone 1. Brk and perhaps a second factor, X (see text), act through the CMB to
repress D-h expression in zone 2. In zone 1, Dpp signaling prevents
Brk repression of D-h expression. Dpp function might be restricted to
repression of brk expression in zone 1. However, it also possible
that Mad acts more directly through the Mad-binding sites.
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