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Fig. 5. Lmx1a is not involved in neural crest development. Chick neural tubes electroporated with Lmx1a-IRES-EGFP (A,B,D,E) or EGFP alone (F,G) 18 hours after electroporation (A,B) or 48 hours after electroporation (D-G). (A,B) Visualization of the early neural crest cell marker Slug (red). (D-G) Visualization of migratory neural crest cell by HNK-1 staining (red). Insets show higher magnification of boxed regions. Arrowhead points to yellow cells co-expressing exogenous Lmx1a and Slug. (C) Quantitative analysis of Slug, Sox9 and Ap2-positive cells in chick embryos electroporated with Lmx1a and EGFP alone. Visualization of early neural crest cells by Sox9 (H,I) and Ap2 (J,K) and neurogenic derivatives of dorsal root ganglia revealed by Isl1 staining (M,N) in neural tubes of wild-type (wt) (H,J,M) and dreher (I,K,N) mouse embryos at indicated stages. Quantitative analysis of Sox9 and Ap2 (L), and MitF-positive cells (O) in wild-type and dreher mouse embryos.

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