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Fig. 2. Ecdysoneless is conserved throughout eukaryotes. Alignment of the Drosophila (Dm) Ecd protein (Swiss-Prot Q9W032) with human (Hs) SGT1 (O95905), and its closest relatives from Arabidopsis thaliana (At; Q9LSM5) and Schizosaccharomyces pombe (Sp; Q9US49), using Clustal W. Black shading indicates amino acid identity, and gray shading indicates similarity if present in two or more of the aligned sequences. The putative ATP/GTP-binding site (P-loop) is marked by the horizontal arrow. Asterisks indicate the positions of the premature termination codons in alleles ecd2, ecdg24 and ecdl(3)23. The arrowhead indicates the conserved proline 656, which is mutated to serine in ecd1.





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