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First published online May 28, 2004

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Wnt LRP co-receptors: team tactics at gastrulation

Intercellular Wnt signalling is required for many patterning processes in vertebrate development. Kelly and colleagues now report that the Wnt co-receptors Lrp5 and Lrp6 - members of the LDL receptor-related family - transduce the Wnt signals that drive posterior patterning during mouse gastrulation (see p. 2803). The researchers show that Lrp5/6 double-mutant embryos fail to establish a primitive streak at gastrulation but establish anterior patterning correctly, a phenotype also seen in Wnt3 mutant embryos. The phenotypes of embryos carrying various combinations of wild-type and mutated Lrp5 and Lrp6 genes indicate that the co-receptors function redundantly. Finally, the phenotype of Lrp5^+/-;Lrp6^-/- embryos - mesodermal defects that closely resemble those seen in Fgf8 and Fgfr1 mutant embryos, and altered anterior patterning that correlates with increased Nodal expression - indicates that Wnt, Fgf and Nodal signals interact to pattern the early mouse embryo.

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Related articles in Development:

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

Olivia G. Kelly, Kathy I. Pinson, and William C. Skarnes
Development 2004 131: 2803-2815. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?