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First published online May 28, 2004

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Cell dynamics of vasculogenesis

Most of what we know about organogenesis comes from static studies of organ anatomy during embryogenesis. But tissue assembly is a dynamic process, involving many individual cell movements. To follow endothelial cell dynamics in vivo during vasculogenesis in quails, Rupp and co-workers used digital time-lapse scanning microscopy to track the movements of endothelial cells tagged with a surface marker (see p. 2887). They describe five types of endothelial cell motion during normal vasculogenesis: global tissue deformation; vascular drift, in which the entire vascular plexus migrates medially; structural rearrangements (such as vascular fusions); individual cell migrations; and cell process extensions. These different cell motions are subtly altered by an vß3 integrin inhibitor, leading the researchers to conclude that the previously reported wide-scale abrogation of vasculogenesis caused by inhibiting this integrin results from disrupting these specific cell movements. This technique will hopefully yield new insights into other morphological processes in development.

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Related articles in Development:

vß3 integrin-dependent endothelial cell dynamics in vivo

Paul A. Rupp, András Czirók, and Charles D. Little
Development 2004 131: 2887-2897. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?