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Fig. 2. Functional redundancy between Lrp5 and Lrp6 in the limb. (A-C) Dorsal views
of skeletal preparations of 18.5 dpc forelimbs stained with Alizarin Red
showing regions of ossification in Lrp5+/- (A),
Lrp5-/- (B) and
Lrp5+/-;Lrp6+/- (C) littermates.
Arrows show ossification centers in the phalanx that are lost in
Lrp5-/- and
Lrp5+/-;Lrp6+/- forelimbs. (D,E)
Ventral views of adult forelimbs showing loss of a post-axial digit (arrow) in
Lrp5+/-;Lrp6+/- mice (E) compared with
a wild-type littermate (D). (F,G) Side views of newborn pups showing normal
limbs (F) compared with defects in a
Lrp5-/-;Lrp6+/- mutant littermate (G).
(H-M) Skeletal preparations of newborn limbs stained with Alizarin Red and
Alcian Blue to indicate bone and cartilage formation, respectively.
Lrp5-/-;Lrp6+/- forelimbs (I,J) and
hindlimbs (L,M) show severe defects compared with a wild-type forelimb (H) and
hindlimb (K). The mutant forelimb in I is from the newborn pictured in G.
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