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Fig. 3. Trajectories of individual primordial endothelial cells, relative to the
surrounding vascular structures. Each panel is a 200x200 µm area with
the embryonic midline on the right, encompassing a 10 hour period of normal
development (see Movie 3 at
http://dev.biologists.org/supplemental).
Circles highlighted by yellow indicate the current position of representative
PECs; lines show their trajectory up to the corresponding time point. Red and
green are used to distinguish medially and laterally oriented motion,
respectively. Even with the subtraction of the medial vascular drift, there is
a heavily favored lateral-to-medial cell migration. In the final panel (12
hours), the experimentally labeled PECs (black) and cell trajectories (yellow
or white) overlay the post-experimentally labeled vasculature (green). PEC #1
first appears in an avascular zone and quickly migrates to a chord
structure.
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