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Fig. 7. In utero delivery of rAAV2-CBA-hGAA preserved diaphragm muscle contractile force in Gaa-/- mice. A dose of 2x108 infectious particles of rAAV2-CBA-hGAA was delivered in utero to Gaa-/- mice (black triangles; n=3). Animals were sacrificed and diaphragm muscle strips were prepared 6 months postpartum. In vitro isometric force-frequency relationships were obtained and compared with those of age-matched, untreated normal C57B6/129-SvJ (black squares; n=3) and Gaa-/-(white circles; n=6) mice.





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