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First published online June 14, 2004

Development 131, 1302e (2004)
© The Company of Biologists Limited
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In this issue

Off with mitosis, on with endocycling

Usually, each step in the cell cycle depends on the completion of the previous stage. But some cells – for example, cardiomyocytes, Drosophila egg follicle cells and many cancer cells – can endocycle, where DNA synthesis continues without mitosis. On p. 3169, Shcherbata and colleagues investigate how Notch signalling controls the mitotic-to-endocytic transition in Drosophila follicle cells at mid-oogenesis. By identifying genes whose transcription is responsive to Notch at this transition, the researchers show that Notch activity: (1) blocks the mitotic (M) phase of the cycle by downregulating the G2/M regulator String; (2) allows G1 entry by activating Hec/CdhFrz, a regulator of the APC ubiquitination complex; and (3) ensures S-phase entry by repressing Dacapo, a cyclinE/CDK complex inhibitor. As the researchers discuss, a better understanding of how external signalling pathways control physiological cell-cycle transitions could identify how abnormal cell-cycle control occurs in cancer cells.


Related articles in Development:

The mitotic-to-endocycle switch in Drosophila follicle cells is executed by Notch-dependent regulation of G1/S, G2/M and M/G1 cell-cycle transitions
Halyna R. Shcherbata, Cassandra Althauser, Seth D. Findley, and Hannele Ruohola-Baker
Development 2004 131: 3169-3181. [Abstract] [Full Text]  




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