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Fig. 1. The cellular players in the healing of a skin wound. The wound is first
‘plugged’ with a fibrin clot, which is infiltrated by inflammatory
cells, fibroblasts and a dense plexus of capillary vessels. The epidermis
migrates forwards from the edges of the wound and from the cut remnants of
hair follicles. Neutrophils and macrophages (blue) emigrate from the wound
capillaries into the wound granulation tissue where they kill microbes, engulf
cell and matrix debris, and release signals that act on the host wound
tissues. Image modified, with permission, from Martin
(Martin, 1997).
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