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Fig. 9. Mitochondrial potential can be maintained by the reversal of the ATP synthase. (A-C) Simultaneous measurement of [Ca2+]c (using fura 2 AM) and of {Delta}{Psi}m (using Rhod123) in mature eggs. Where indicated, oligomycin (60 µM), FCCP (1 µM), malonate (20 mM) and rotenone (5 µM) are added to the bath. (D,E) Schematic representations of a mitochondria and the effect of mitochondrial inhibitors on the proton fluxes generated at the respiratory chain (D, CN–, rotenone, malonate) or at the F0/F1 synthase (E, oligomycin).





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