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Fig. 7. Model of myocardial morphogenesis. The spatial organization of myocardial
chamber progenitors at 40% epiboly and the locations of their progeny at
tailbud and mid-somitogenesis stages suggest orderly migration of these
populations. (A-I) Schematic representations of zones containing ventricular
myocardial progenitors (red) or atrial myocardial progenitors (yellow). Zones
containing both ventricular and atrial progenitors are depicted in red and
yellow stripes. (A) Representation of myocardial fate map at 40% epiboly;
primary data shown in Fig. 2B.
(B-F) Frames from an animated model of myocardial morphogenesis (see Movie 1
at
http://dev.biologists.org/supplemental);
lateral views, dorsal towards the right, at (B) 40% epiboly, (C) shield, (D)
70% epiboly, (E) 85% epiboly and (F) tailbud stages. Background images
adapted, with permission, from Karlstrom and Kane
(Karlstrom and Kane, 1996).
(G-I) Dorsal views, anterior towards the top, depicting myocardial progenitor
zones within the LPM at (G) 5 somites, (H) 15 somites and (I) 22 somites.
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