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Fig. 3. Disruption of cortical laminar and radial glial markers. (A,B)
Tbr1, expressed in the subplate and upper cortical plate in the
wild-type (A), indicates abnormal migration of cortical neurons in the
Psen1 mutant (B). (C,D) p75, which is detected in the
subplate and future layer VI in the wild type (C), is downregulated in the
mutant and nearly absent from the ventricular zone (D). (E,F) Cdh6
expression labels neurons more sparsely in the mutant (F) than in wild type
(E), particularly in the ventricular and intermediate zone (F). (G-J) Radial
glia markers in the ventricular zone are severely downregulated in the mutant
(H,J) in comparison with wild type (G,I). (G,H) Dab1. (I,J)
Pax6. (K,L) Notch pathway activity, visualized by Hes5
expression in the wild type (K) is dramatically reduced in the mutant (L). In
situ hybridization on coronal sections through E17.5 (A-F) or E16.5 (G-L)
cortex. vz, ventricular zone.
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