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Fig. 6. The Notch pathway regulates Fzr independently from String and Dacapo. (A) Although cells ectopicly expressing dacapo (arrowhead) do not undergo endocycles and have smaller nuclei (arrowhead in A''), they express normal levels of Fzr (arrowhead in A''') compared with wild-type cells (arrow) (hsFlp/fzrG0326; UAS-dap; UASGFP act<FRT-CD2-FRT<Gal4). (B) The normal Fzr expression is observed in most cells overexpressing dacapo (hsFlp/fzrG0326; UAS-dap; UASGFP act<FRT-CD2-FRT<Gal4) or cyclinE (hsFlp/fzrG0326; UAS-cycE/UASGFP act<FRT-CD2-FRT<Gal4). (C) Premature expression of fzr (arrowhead in C') causes precocious endocycles (large nuclei, arrowhead in C'') but does not affect string expression (C''', arrowhead indicates UAS-fzr cells, arrow – wild-type cells). (D) No effect on string or dacapo expression was observed upon premature expression of fzr (the diagram shows that UAS-fzr and wild-type follicle cells show close to equal percentage of cells with Dacapo and String staining, hsFlp; UAS-fzr/UASGFP act<FRT-CD2-FRT<Gal4;6.4-string-lacZ or dap5gm). Green, GFP; red, ß-gal; blue, DAPI.

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