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Fig. 7. Ds regulates Wg signaling during leg development. Removal of one dose of several genes that participate in the Wg pathway modifies the ds phenotype in the leg. Proximal leg of a wild-type (A) and ds mutant (B,C,D,E) specimens. Right panels show a higher magnification of the third tarsal joint for each genotype. In all panels, proximal is to the right and distal to the left. (A) The wild-type tarsus is divided into five segments connected by four tarsal joints (asterisks). (B) In dsZ/ds¹ mutants, tarsal segments are shortened and some tarsal joints are incomplete. (C) Insufficiency of the Wg pathway, caused by removal of one dose of dsh, increases the severity of the dsZ/ds¹ phenotype. The length of the segments is reduced and most of the tarsal joints are almost eliminated (arrowhead, right). In several cases the tarsal joints are completely absent (not shown). Reduction of nkd, by one dose, produces an increase in Wg pathway signalling. (D) The leg phenotype of ds^38k/ds¹ is similar that shown in B. (E) Elimination of one dose of nkd in ds^38k/ds¹ background completely rescues the tarsal joints and the size of the tarsal segments is recovered almost to that of wild type. dsZ/ds¹ and ds^38k/ds¹ are considered mild allelic ds combinations with respect to the leg phenotype. A representative phenotype for each genotype was illustrated. dsh^V6 or nkd^1E89 are null alleles.

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