QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

Help viewing high resolution images Return to article

Fig. 3. Osr2^{tm1Jian/tm1Jian} mutant mice are born with open eyelids and cleft palate. (A,B) Dorsal view of heterozygous (A) and homozygous (B) mutant newborn heads. (C,D) Frontal sections of heterozygous (C) and homozygous (D) newborn mutant heads. (E,F) Ventral view of stained skeletal preparations of heterozygous (E) and homozygous (F) mutant neonatal skulls. Arrowheads indicate palatal processes of the palatine bones that have fused to each other in the heterozygous mouse (E) but are absent in the homozygous mutant, exposing the presphenoid bone (marked with an asterisk) underneath (F). The tympanic rings are significantly thicker in the homozygous mutant than in the heterozygous mouse (arrows). (G,H) Comparison of tympanic rings with associated middle ear ossicles and the Meckel's cartilage dissected from wild-type (G) and homozygous mutant (H). Whereas the mutant tympanic ring is significantly thicker than that of the wild type, the associated Meckel's cartilage and middle ear ossicles are similar in size in wild-type and mutant newborns. e, eye; i, incus; m, malleus; mc, Meckel's cartilage; mm, manubrium of the malleus; p, palate; t, tongue; tr, tympanic ring.

Return to article