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Fig. 4. Histological analysis of palate development in Osr2tm1Jian/tm1Jian mutants. (A,B) At E13.5, wild-type (A) and Osr2tm1Jian/tm1Jian homozygous mutant (B) embryos exhibited similar palatal shelf size and shape. (C,D) At E14.5, palatal shelves appeared retarded in the homozygous mutant (D) compared with the heterozygous littermate (C). (E,F) At E15.0, the heterozygous mutant (E) palatal shelves had elevated to the horizontal position above the tongue, while the homozygous mutant (F) palatal shelves were still vertically oriented. (G,H) At E15.5, the heterozygous mutant palatal shelves had made contact and initiated fusion at the midline, but the palatal shelves remained separated from each other in the homozygous mutant littermate (H). (I,J) At E16.5, the heterozygous mutant (I) palatal shelves had completed fusion, but the homozygous mutant (J) palatal shelves were retarded and separate from each other. p, palatal shelf, t, tongue.





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