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First published online June 28, 2004

Development 131, 1403e (2004)
© The Company of Biologists Limited
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In this issue

Quick chick axis inhibitor


Any isolated fragment of a chick embryo, right up until the time of primitive streak formation, is spontaneously able to form a complete embryonic axis. Why then does only a single axis form in intact embryos? New results by Bertocchini et al. (p. 3381) reveal that the normal site of axis formation inhibits other regions from initiating this process. Vg1, synthesised in the posterior marginal zone, induces a fast-moving inhibitor that travels across the 3-mm embryo in under 6 hours, and which acts either in parallel with or upstream of Nodal and Chordin. This inhibitor is distinct from Cerberus, a Nodal antagonist produced by the extraembryonic hypoblast. Instead, the authors suggest that it belongs to the Lefty family of long-range Nodal antagonists. Bertocchini and colleagues also find a new role for FGFs in embryonic axis initiation, and suggest that FGF8 acts synergistically with Nodal to initiate primitive streak formation.


Related articles in Development:

Determination of embryonic polarity in a regulative system: evidence for endogenous inhibitors acting sequentially during primitive streak formation in the chick embryo
Federica Bertocchini, Isaac Skromne, Lewis Wolpert, and Claudio D. Stern
Development 2004 131: 3381-3390. [Abstract] [Full Text]  




This Article
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