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Fig. 7. Proposed model for PAL-1 repression in the germline. (A) GLD-1 represses the translation of both pal-1 and mex-3 in the distal gonad arm, while MEX-3 represses pal-1 translation in the proximal gonad arm. GLD-1 and MEX-3, shown in blue and green respectively, have graded expression patterns in the gonad, with lowest levels found in the bend. A leaky switch from GLD-1- to MEX-3-mediated repression may account for the restricted PAL-1 expression (red) in the bend of the gonad arm. (B) GLD-1 binds the GRE and may repress pal-1 translation after ribosome loading.





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