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Fig. 1. Enhancer of Otx2 expression in forebrain and midbrain at 5'
upstream. (A) The location of the #13 fragment that exhibited the enhancer
activity in forebrain midbrain. EP/AN indicates the position of the EP and AN
enhancer at –92.5 to –90 kb. (B) ß-Gal expression driven by
#13 (a-f,m,q) and by endogenous enhancers in
Otx2+/
acZ knock-in embryos (g-j,l,p), at the
stages indicated. Endogenous Otx2 mRNA expression is presented in
k,n,o. (a,k-m) frontal views; (b-j) lateral views (anterior is towards the
left); (n-q) frontal sections at the telencephalic level. Arrows and
arrowheads indicate expression by the 1.8 kb promoter and the position of the
isthmus, respectively. Double arrowheads in c indicate the absence of the
ß-gal expression in the most anterior neural plate, which may correspond
to future telencephalon. Scale bars: 100 µm in a,b,g; 400 µm in
c-f,h-q.
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