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Fig. 2. Deletion analysis of FM enhancer. (A) Fine mapping of the FM enhancer. (B) Schematic organization of the AH 1.4 kb subfragment and sequence alignment of the CR region in mouse, human and Xenopus. (C) ß-Gal expression at E10.5 driven by the AH 1.4 kb fragment (a), by the CR domain of the fragment (b) and by the AH 1.4 kb fragment exhibiting a mutation in the OTX binding site (c), in both TCF-binding sites (d) and in the PAX-binding site (e). Expression in midbrain is lost in b; furthermore, only residual expression exists in midbrain (arrowhead). Arrows indicate ß-gal expression in cephalic mesenchyme driven by the 1.8 kb promoter. Scale bars: 400 µm.





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