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Fig. 7. Cooperation between Otx1 and Otx2 under FM and FM2 enhancers. (A) Histological features of a series of double mutants at E12.5; the genotype of each mutant is indicated at the left. Among mutants not shown, defects were either absent or subtle in Otx2{Delta}FM2/{Delta}FM2, Otx1+/–Otx2+/{Delta}FM2, Otx1–/–, Otx2+/–, Otx2{Delta}FM/{Delta}FM2, Otx1+/–Otx2+/{Delta}FM, Otx2{Delta}FM/{Delta}FM, Otx1+/–Otx2{Delta}FM2/{Delta}FM2 and Otx1–/–Otx2+/{Delta}FM2 mutants. Otx1+/–Otx2{Delta}FM2/– was affected to the same extent as Otx2{Delta}FM/– (f); furthermore, defects in Otx1+/–Otx2{Delta}FM/– were as severe as those in Otx1–/–Otx2{Delta}FM/{Delta}FM (h). Arrowheads indicate the position of the isthmus. Scale bars: 400 µm. (B) Marker analysis of the defects in Otx1–/–Otx2{Delta}FM/{Delta}FM at E10.5; Otx2 (a), Pax6 (b), Fgf8 (c) and Emx2 (d) expression. See Fig. 3C for the expression in wild-type embryos. Arrows in a and b indicate residual Otx2- and Pax6-positive domains, respectively. Scale bars: 400 µm.





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