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Fig. 8. Genome organization in fish Otx loci. (A) Locations of the 22 domains conserved among mouse, human and Xenopus in pufferfish and zebrafish Otx loci. No homologous region existed in the FrOtx1 locus. Domains that exhibited enhancer activity are shown by red bars. Regions homologous to the mouse FM2 enhancer region (indicated by a yellow bar) were also not found in fish genomes. White boxes indicate the coding regions. The numbers below each bar represent sequence identity with the mouse counterpart in percentage terms. ß-Gal staining in b yields expression directed by a 600 bp region covering domain ß in zebrafish Otx2. (B) Sequence alignment of domain ß in mouse, zebrafish and two pufferfish Otx2 loci. Red square indicates a sequence conserved throughout gnathostome Otx2 FM regions, the significance of which is currently unknown. Scale bars: 400 µm.





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