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Fig. 5. A role for FGF in primitive streak formation. In gain-of-function experiments (A-C), misexpression of FGF4 (or FGF8, not shown) initiates the formation of an ectopic primitive streak in intact embryos at pre-streak stages (A,B) as well as at stage 3 (C). The induced axis (arrows) expresses brachyury (A,C) and chordin (B). Loss-of-function experiments: when beads soaked in SU5402 are grafted in the posterior area pellucida (D), primitive streak formation is inhibited (F) or the streak displaced away from the beads (G). By contrast, embryos grafted with control beads develop normally (E).





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