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Fig. 7. Disruption of induction of ureter growth and RET/GDNF feedback signaling during metanephric organogenesis. (A) During onset of ureter growth (arrow) in wild-type embryos, Gdnf transcription is upregulated in the induced metanephric mesenchyme. (B) Ureter growth and Gdnf upregulation are not induced in mutant embryos (E11.25). (C) By E11.5, the ureter has branched once and expresses high levels of Ret (arrowheads) and Gdnf is maintained in the induced metanephric mesenchyme. (D) By contrast, ureter development is arrested and Gdnf expression lost in Grem1-deficient embryos. (E,F) Analysis of Ret and Gdnf expression on sections of E11.5 embryos confirms the disruption of RET/GDNF epithelial-mesenchymal feedback signaling in mutant embryos. cm, condensing mesenchyme; ub, ureteric bud; wd, Wolffian duct. (E,F) Transverse sections at the level of hind limb buds.





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