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Fig. 7. Abnormal expression of ß-catenin and Lef/Tcf family members in
orpk mice. In wild-type pancreatic sections ß-catenin is
predominately localized to the cell membrane (A; arrows in higher
magnification image, C). In orpk mice, cytoplasmic ß-catenin
localization in dilated ducts (arrowheads) is increased (B; and at higher
magnification in D). (E) Expression of Lef/Tcf family members in control
littermates (first lane) and orpk mice (second and third lane). Actin
was used as a control gene.