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Fig. 4. dLGN projection neurons contribute to the development of retino-geniculate connectivity. (A-E) Coronal sections of dLGN in P9 rats (n=18) that received injections of retrogradely transported beads-U0126 in the primary visual cortex, and quantification of relative contralateral, ipsilateral and overlap areas in the dLGN. Both ipsilateral (A) and contralateral (B) projections are diffusely distributed in the dLGN. The relative ipsilateral (C) and contralateral (D) areas of U0126-treated animals (n=18) are statistically greater than those of control animals (n=10), (Student's t-test, P<0.05 respectively). (E) The relative overlap area of U0126-treated animals is larger than that of control animals. Error bars depict the s.d. Dashed lines indicate the relative eye-specific areas in normal P9 rats. Scale bar: 200 µm.





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